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[西维因处理大鼠的己巴比妥睡眠和血清胆碱酯酶活性变化]

[Changes in the hexobarbital sleep and serum cholinesterase activity of rats treated with carbaryl].

作者信息

Dobreva V, Kaloianova F

出版信息

Probl Khig. 1988;13:109-14.

PMID:3149406
Abstract

Studies are carried out on the changes during the hexobarbital sleep and the cholinesterase activity in male rats subject to multiple oral introduction of carbaryl in relative low doses (40 mg/kg daily). The changes in the hexobarbital sleep and the relative weight of the liver during the 21-day treatment with carbaryl (40 mg/kg) show acceleration of the biotransformation processes in the organism of 6-month male albino rats. The raised activity of the serum cholinesterase activity can be accepted as an expression of the reinforced synthesis of protein in the liver.

摘要

对雄性大鼠以相对低剂量(每日40毫克/千克)多次口服西维因后,进行了关于己巴比妥睡眠期间变化及胆碱酯酶活性的研究。在用西维因(40毫克/千克)进行21天治疗期间,己巴比妥睡眠及肝脏相对重量的变化表明,6个月大的雄性白化大鼠机体中的生物转化过程加速。血清胆碱酯酶活性升高可被视为肝脏中蛋白质合成增强的一种表现。

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