Welsh R M, Kiessling R W
Scand J Immunol. 1980;11(4):363-7. doi: 10.1111/j.1365-3083.1980.tb00001.x.
Lymphocytic choriomeningitis virus (LCMV) induced low levels of natural killer (NK) cell acitivity in C57BL6 mutant beige (bg/bg) mice, which had previously been reported to have no cytotoxic NK cells. NK cell-mediated lysis by bg/bg splenocytes was observed against a cell line (YAC-1) very sensitive to NK cell cytotoxicity, but not appreciably against a less sensitive cell line (L-929). The bg/bg mutant mice with this very low NK cell activity and control strains of mice (by/+, C57BL6) with high NK cell activity synthesized comparable amounts of virus and interferon in the spleen, suggesting that NK cells may not play a significant role, but not appreciably against a less sensitive cell line (L-929). The bg/bg mutant mice with this very low NK cell activity and control strains of mice (by/+, C57BL6) with high NK cell activity synthesized comparable amounts of virus and interferon in the spleen, suggesting that NK cells may not play a significant role, but not appreciably against a less sensitive cell line (L-929). The bg/bg mutant mice with this very low NK cell activity and control strains of mice (by/+, C57BL6) with high NK cell activity synthesized comparable amounts of virus and interferon in the spleen, suggesting that NK cells may not play a significant role in curtailing viral synthesis before the advent of the specific immune response mechanisms.
淋巴细胞性脉络丛脑膜炎病毒（LCMV）在C57BL6突变型米色（bg/bg）小鼠中诱导出低水平的自然杀伤（NK）细胞活性，此前有报道称该小鼠没有细胞毒性NK细胞。观察到bg/bg脾细胞对一种对NK细胞细胞毒性非常敏感的细胞系（YAC-1）具有NK细胞介导的裂解作用，但对敏感性较低的细胞系（L-929）则没有明显的裂解作用。这种NK细胞活性极低的bg/bg突变小鼠和NK细胞活性高的对照小鼠品系（by/ +，C57BL6）在脾脏中合成的病毒和干扰素量相当，这表明NK细胞可能不会发挥重要作用，但对敏感性较低的细胞系（L-929）则没有明显作用。这种NK细胞活性极低的bg/bg突变小鼠和NK细胞活性高的对照小鼠品系（by/ +，C57BL6）在脾脏中合成的病毒和干扰素量相当，这表明NK细胞可能不会发挥重要作用，但对敏感性较低的细胞系（L-929）则没有明显作用。这种NK细胞活性极低的bg/bg突变小鼠和NK细胞活性高的对照小鼠品系（by/ +，C57BL6）在脾脏中合成的病毒和干扰素量相当，这表明在特异性免疫反应机制出现之前，NK细胞在抑制病毒合成方面可能不会发挥重要作用。
