Mannan A, Rahman M S
Bangladesh Med Res Counc Bull. 1977 Dec;3(2):87-93.
Long term maintenance of male rats of Long Evans variety following mercuric chloride induced uremia has shown an altered intramolecular structure of muscle glycogen with no significant difference in muscle glycogen content. The structure of muscle glycogen in these uremic rats when compared to sham control rats differed significantly from the structure of liver glycogen observed earlier in nephrectomized rats (Mannan et al., 1975). Biochemical analysis of muscle glycogen revealed a significant inverse relationship between the muscle and liver glycogen structure in terms of number of segments and number of non-reducing ends. Thus, an abnormal or altered muscle glycogen intramolecular structure of uremic rats is compatible with the observation of hypoglycemic state. Attributions of this to defects in glycogenolysis due to altered configuration in intramolecular structure of glycogen molecule are discussed.
对氯化汞诱导的尿毒症雄性 Long Evans 品系大鼠进行长期维持观察，结果显示肌肉糖原的分子内结构发生改变，但肌肉糖原含量无显著差异。与假手术对照大鼠相比，这些尿毒症大鼠的肌肉糖原结构与之前在肾切除大鼠中观察到的肝糖原结构有显著差异（Mannan 等人，1975 年）。对肌肉糖原的生化分析表明，在片段数量和非还原端数量方面，肌肉和肝糖原结构之间存在显著的负相关关系。因此，尿毒症大鼠肌肉糖原分子内结构的异常或改变与低血糖状态的观察结果相符。本文讨论了将此归因于糖原分子内结构改变导致糖原分解缺陷的情况。
