Larrea J L, Núñez L, Gil Aguado M, Iglesias A, Celemín D, López A, García S, Cuesta M V, Vigeriego M
Med Clin (Barc). 1980 Jun 10;75(1):20-3.
Human albumin and dextran 70 were used as volume expanders in extracorporeal circulation in two homogeneous series of patients. Comparative results were statistically processed. No significant differences were observed either to early postoperative bleeding or needed volume of transfused blood. Postoperative complications neither developed in the two groups of patients. The total number of platelets showed a 50 percent decrease in relation to basal extraction figures and those after immediate heparin neutralization. Results of platelet function tests were similar in both series, except for a statistical significant decrease in ADP-induced platelet aggregation in the group with dextran 70. Such decrease, however, was not followed by an increase of postoperative bleeding. Thus, dextran 70 has showed to be a valuable substitute for human albumin in extracorporeal circulation.
在两组同类患者的体外循环中，人白蛋白和右旋糖酐70被用作容量扩充剂。对比较结果进行了统计学处理。在术后早期出血或所需输血量方面均未观察到显著差异。两组患者均未出现术后并发症。与基础提取数据及肝素立即中和后的血小板总数相比，血小板总数下降了50%。除右旋糖酐70组中ADP诱导的血小板聚集有统计学显著下降外，两个系列的血小板功能测试结果相似。然而，这种下降并未伴随术后出血的增加。因此，右旋糖酐70已被证明是体外循环中人类白蛋白的一种有价值的替代品。
