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识别大鼠视网膜中不同细胞类型的单克隆抗体。

Monoclonal antibodies which recognize different cell types in the rat retina.

作者信息

Barnstable C J

出版信息

Nature. 1980 Jul 17;286(5770):231-5. doi: 10.1038/286231a0.

Abstract

Seven monoclonal antibodies have been produced against a membrane preparation from adult rat retina. Three antibodies reacted with particular regions of rat photoreceptor cell surfaces: RET-P1 labelled the cell bodies, outer and inner segments (rods but not cones), RET-P2 labelled only outer segments and RET-P3 labelled only the cell bodies. Three antibodies reacted with glial cells; RET-G2 and RET-G3 were specific for Müller cells, RET-G1 also labelled glia elsewhere in brain. The seventh antibody (RET-N1) reacted with many types of neuronal cells.

摘要

已经制备了七种针对成年大鼠视网膜膜制剂的单克隆抗体。三种抗体与大鼠光感受器细胞表面的特定区域发生反应:RET-P1标记细胞体、外段和内段(视杆细胞而非视锥细胞),RET-P2仅标记外段,RET-P3仅标记细胞体。三种抗体与神经胶质细胞发生反应;RET-G2和RET-G3对米勒细胞具有特异性,RET-G1也标记大脑其他部位的神经胶质细胞。第七种抗体(RET-N1)与多种类型的神经元细胞发生反应。

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