Hindersin P, Heidrich R
Psychiatr Neurol Med Psychol (Leipz). 1980 Jun;32(6):328-37.
A quantitative immunochemical determination of the plasmin inhibitors alpha-1-antitrypsin, alpha-2-macroglobulin, and antithrombin-III of the fibronolytic system was carried out from normal, inflammatorily changed, and essentially sanguineous fluids. The low total inhibitor concentration in the cerebrospinal fluid is due to the 'restricted diffusion' caused by the blood/brain barrier function and the lacking synthesis for these proteins in the central nervous system. The inhibitor concentrations which in functional disorders of the blood/sbrain barrier and/or direct entering of blood are still--low as compared to the plasma produce a dissociation of the plasmin-inhibitor complex. The lacking interaction between the active enzyme and the inhibitor enables the occurrence of a free fibrinolytic activity in the cerebrospinal fluid.
对正常、炎症改变及主要为血性的液体进行了纤溶系统中纤溶酶抑制剂α-1-抗胰蛋白酶、α-2-巨球蛋白和抗凝血酶III的定量免疫化学测定。脑脊液中总抑制剂浓度较低是由于血脑屏障功能导致的“扩散受限”以及中枢神经系统中这些蛋白质合成的缺乏。与血浆相比，在血脑屏障功能紊乱和/或血液直接进入时抑制剂浓度仍然较低，这导致纤溶酶-抑制剂复合物解离。活性酶与抑制剂之间缺乏相互作用使得脑脊液中出现游离的纤溶活性。
