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[δ-催眠肽诱导睡眠期间大鼠脑视上核中的蛋白质和RNA浓度]

[Protein and RNA concentration in the supraoptic nucleus of the rat brain during sleep induced by delta-hypnogenic peptide].

作者信息

Demin N N, Karmanova I G, Maksimuk V F, Rubinskaia N L

出版信息

Zh Evol Biokhim Fiziol. 1980 May-Jun;16(3):257-60.

PMID:6157271
Abstract

It has been shown that specific sleep induced by suboccipital injection of a synthetic delta-hypnogen peptide (delta-sleep inducing peptide, according to M. Monnier) is not accompanied in rats by accumulation of proteins and RNA in the supraoptic nuclear glia--the anabolic process characteristic for natural sleep. At the same time, during this artificial sleep protein concentration in the cytoplasm of the neurones in this nucleus increased due to the corresponding reduction of cytoplasmic volume which is absent during natural sleep. These phenomena, observed during the sleep induced by delta-hypnogen peptide, are similar to those described during phylogenetically more ancient type of rest, i. e. cataleptiform immobility, which is typical of the lower vertebrates only.

摘要

已经表明,通过枕下注射合成的δ-催眠原肽(根据M. 莫尼尔的说法,即δ-睡眠诱导肽)诱导的特定睡眠,在大鼠中并不伴随着视上核神经胶质中蛋白质和RNA的积累——这是自然睡眠所特有的合成代谢过程。与此同时,在这种人工睡眠期间,由于细胞质体积相应减少,该核中神经元细胞质中的蛋白质浓度增加,而自然睡眠期间不存在这种情况。在由δ-催眠原肽诱导的睡眠期间观察到的这些现象,类似于在系统发育上更古老的休息类型,即僵住不动中所描述的现象,僵住不动仅在低等脊椎动物中典型存在。

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1
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Zh Evol Biokhim Fiziol. 1980 May-Jun;16(3):257-60.
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Topochemical aspects of nucleic-acid and protein metabolism within the neuron-neuroglia unit of the hypothalamic supraoptic nucleus.下丘脑视上核神经元 - 神经胶质细胞单元内核酸和蛋白质代谢的拓扑化学方面
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