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阿司匹林对犬慢性胃溃疡愈合的影响。

Influence of aspirin on healing of chronic gastric ulcers in dogs.

作者信息

Takeuchi K, Okabe S, Takagi K, Umeda N

出版信息

Digestion. 1977;16(1-2):51-6. doi: 10.1159/000198055.

DOI:10.1159/000198055
PMID:615737
Abstract

Gastric ulcers induced in dogs by transserosal injection of 1 ml of 40% acetic acid healed completely by the 7th week after ulceration and never reulcerated during the observation period up to 12 weeks. Acetic acid ulcers in the active (at 1 week), quiescent (3 weeks) or healed (at 7 weeks) stages were not influenced by the daily administration of aspirin 2 g/dog/day for for 5 consecutive weeks. All examinations were done by gastroscopy in addition to macroscopical and histological observations at autopsy.

摘要

通过经浆膜注射1毫升40%乙酸在犬身上诱发的胃溃疡在溃疡形成后第7周完全愈合,并且在长达12周的观察期内未再次发生溃疡。处于活动期(1周时)、静止期(3周时)或愈合期(7周时)的乙酸溃疡,连续5周每天给每只犬服用2克阿司匹林均未受影响。除尸检时的大体和组织学观察外,所有检查均通过胃镜进行。

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1
Influence of aspirin on healing of chronic gastric ulcers in dogs.阿司匹林对犬慢性胃溃疡愈合的影响。
Digestion. 1977;16(1-2):51-6. doi: 10.1159/000198055.
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Effect of histamine and aspirin on healing of standardized gastric ulcers in dogs.组胺和阿司匹林对犬标准化胃溃疡愈合的影响。
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Gastrointest Endosc. 1971 Nov;18(2):56-8. doi: 10.1016/s0016-5107(71)74029-2.
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[Experimental studies on gastric ulcer (6). Endoscopical evaluation of healing processes of acetic acid ulcer in rats (2): Healing, recurrence and relapse of ulcer].[胃溃疡的实验研究(6)。大鼠醋酸溃疡愈合过程的内镜评估(2):溃疡的愈合、复发和再发]
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Effects of misoprostol on delayed ulcer healing induced by aspirin.米索前列醇对阿司匹林所致溃疡愈合延迟的影响。
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Dig Dis Sci. 1989 Jul;34(7):1035-42. doi: 10.1007/BF01536370.

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