Balfour D J
Arch Int Pharmacodyn Ther. 1980 May;245(1):95-103.
The acute intragastric and chronic oral administration of nicotine had no effect on plasma corticosterone levels although both procedures induced tolerance to the stimulatory effects of acute subcutaneous nicotine (0.4 mg/kg) on corticosterone secretion. Chronic oral nicotine (5.4 mg/kg/day) also had little effect on brain 5-hydroxyindoles and no changes in plasma corticosterone or brain 5-hydroxyindoles were seen in response to nicotine withdrawal. Oral nicotine was not an adequate substitute in rats made behaviourally dependent upon nicotine injections. It is concluded that route of administration greatly influences the biochemical and behavioural properties of nicotine.
急性胃内给予和慢性口服尼古丁对血浆皮质酮水平没有影响，尽管这两种给药方式都会诱导对急性皮下注射尼古丁（0.4毫克/千克）刺激皮质酮分泌作用的耐受性。慢性口服尼古丁（5.4毫克/千克/天）对脑5-羟吲哚也几乎没有影响，并且在尼古丁戒断后，血浆皮质酮或脑5-羟吲哚未见变化。口服尼古丁不能充分替代对尼古丁注射产生行为依赖性的大鼠。得出的结论是，给药途径极大地影响尼古丁的生化和行为特性。
