Balfour D J, Khullar A K, Longden A
Pharmacol Biochem Behav. 1975 Mar-Apr;3(2):179-84. doi: 10.1016/0091-3057(75)90145-8.
The administration of nicotine (0.4 mg/kh) to unstressed rats caused a rise in plasma corticosterone which persisted for 60 minutes and a fall in hippocampal 5-hydroxytryptamine (5-HT) at 45 minutes followed by a rise at 60 minutes. In rats which were stressed by being placed on an elevated platform, nicotine caused a reduction in hippocampal 5-HT at 45 and 75 minutes but did notaffect the plasma corticosterone concentration. Rats studied 16 hours after the last injection of a course of treatment with metypone had much reduced levels of plasma corticosterone and hippocampal 5-HT. Under the present conditions metyrapone also much diminished the effects of nicotine on plasma corticosterone levels in unstressed rats but had little effect on the response to stress.
给未受应激的大鼠注射尼古丁（0.4毫克/千克）会导致血浆皮质酮水平升高，该升高持续60分钟，同时海马5-羟色胺（5-HT）在45分钟时下降，随后在60分钟时上升。对于被放置在高架平台上而受到应激的大鼠，尼古丁会在45分钟和75分钟时导致海马5-HT减少，但不影响血浆皮质酮浓度。在最后一次注射甲吡酮进行一个疗程治疗16小时后进行研究的大鼠，其血浆皮质酮和海马5-HT水平大幅降低。在当前条件下，甲吡酮也大大减弱了尼古丁对未受应激大鼠血浆皮质酮水平的影响，但对应激反应影响不大。
