Gupta G S, Chopra V K
Strahlentherapie. 1980 Aug;156(8):579-82.
Studies on spleen have been performed following administration of iodine-125 in perchlorate-treated rats. Although DNA levels did not change appreciably, there was a significant decrease in total RNA following incorporation of iodine-125. Associated with the changes in RNA, there was a significant rise in acid phosphatase and total as well as Mg-dependent ATPases. Increased activity of acid phosphatase seems to be related to the loss of lymphocytes, whereas the rise in ATPase appeared to be associated with cells of red pulp of spleen. It is suggested that damage to the spleen after administration of iodine-125 is due to the Auger effect.
在给高氯酸盐处理过的大鼠注射碘-125后，对其脾脏进行了研究。尽管DNA水平没有明显变化，但在碘-125掺入后，总RNA显著减少。与RNA的变化相关，酸性磷酸酶以及总ATP酶和镁依赖性ATP酶均显著升高。酸性磷酸酶活性的增加似乎与淋巴细胞的损失有关，而ATP酶的升高似乎与脾红髓细胞有关。有人认为，注射碘-125后脾脏的损伤是由于俄歇效应。
