P物质C末端七肽与6位N5 - 二甲基谷氨酰胺的合成及收缩活性。活性位点研究。
Synthesis and contractile activity of the C-terminal heptapeptide of substance P with N5-dimethyl glutamine in the 6-position. Active site studies.
作者信息
Poulos C P, Pinas N, Theodoropoulos D
出版信息
Experientia. 1980 Sep 15;36(9):1104-5. doi: 10.1007/BF01965995.
PMID:6158458
Abstract
The synthesis and testing of [N5-dimethyl-Gln6]-SP5-11 showed 37 +/- 12% contractile activity relative to SP, and intrinsic efficacy 98 +/- 4%. This finding indicates that the carboxamide groups of the dual Gln5-Cln6 moiety are not equally related with the contractile response of the C-terminal heptapeptide of SP.
摘要
[N5-二甲基-Gln6]-SP5-11的合成与测试表明，相对于速激肽（SP），其具有37±12%的收缩活性，内在活性为98±4%。这一发现表明，双Gln5-Cln6部分的羧酰胺基团与SP C末端七肽的收缩反应的相关性并不相同。
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