Lipkowski A W, Osipiak B, Gumulka W S
Life Sci. 1983;33 Suppl 1:141-4. doi: 10.1016/0024-3205(83)90464-2.
Analogs of substance P in which the N-terminal part of native peptide was replaced by an enkephalin active fragment have been synthesized. We found this peptide to be as active as substance P on the GPI test. The analogs were completely inactive on GPI opiate test; the opiate activity was observed on MVD and RVD tests. Surprisingly, we found that SP-activity was reduced by naloxone.
已经合成了P物质的类似物，其中天然肽的N端部分被脑啡肽活性片段取代。我们发现这种肽在GPI试验中与P物质一样具有活性。这些类似物在GPI阿片试验中完全无活性；在MVD和RVD试验中观察到阿片活性。令人惊讶的是，我们发现纳洛酮可降低P物质活性。
