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抑肽酶在治疗胎盘早剥伴消耗性凝血病及子宫收缩乏力中的应用

Trasylol in the management of abruptio placentae with consumption coagulopathy and uterine inertia.

作者信息

Sher G

出版信息

J Reprod Med. 1980 Sep;25(3):113-8.

PMID:6159472
Abstract

A study was conducted on 40 patients with abruptio placentae complicated by intrauterine death of the fetus, consumption coagulopathy and uterine inertia. All patients had severe hyperfibrinolysis (FDP > 300 microgram/ml). Following correction of shock, amniotomy was performed, intrauterine pressure catheters were placed, and oxytocin infusions were begun in all cases. The diagnosis of uterine inertia was made when the cervix failed to dilate following six hours of this treatment. After diagnosing uterine inertia, 18 patients (group B) did not. All but one patient in group A showed a marked improvement in the associated consumption coagulopathy and a rapid reawakening of uterine activity with progress to spontaneous vaginal delivery. Thirteen patients in group B did not show prepartum improvement in consumption coagulopathy or a resumption of uterine activity. These patients required cesarean section. There were two maternal deaths in group B; the overall complication rate in this group was greater than in group A.

摘要

对40例胎盘早剥合并胎儿宫内死亡、消耗性凝血病及子宫收缩乏力的患者进行了一项研究。所有患者均有严重的纤维蛋白溶解亢进(纤维蛋白降解产物>300微克/毫升)。在纠正休克后,所有病例均行人工破膜、放置宫内压力导管并开始静脉滴注缩宫素。在该治疗6小时后宫颈未扩张时诊断为子宫收缩乏力。诊断为子宫收缩乏力后,18例患者(B组)未(采取进一步措施)。A组除1例患者外,所有患者的相关消耗性凝血病均有明显改善,子宫活动迅速恢复并进展至自然阴道分娩。B组13例患者的消耗性凝血病在产前未改善,子宫活动也未恢复。这些患者需要剖宫产。B组有2例产妇死亡;该组的总体并发症发生率高于A组。

相似文献

1
Trasylol in the management of abruptio placentae with consumption coagulopathy and uterine inertia.抑肽酶在治疗胎盘早剥伴消耗性凝血病及子宫收缩乏力中的应用
J Reprod Med. 1980 Sep;25(3):113-8.
2
Pathogenesis and management of uterine inertia complicating abruptio placentae with consumption coagulopathy.并发胎盘早剥伴消耗性凝血病的子宫收缩乏力的发病机制与处理
Am J Obstet Gynecol. 1977 Sep 15;129(2):164-70. doi: 10.1016/0002-9378(77)90739-6.
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Abruptio placentae with coagulopathy: a rational basis for management.胎盘早剥伴凝血功能障碍:处理的合理依据
Clin Obstet Gynecol. 1985 Mar;28(1):15-23. doi: 10.1097/00003081-198528010-00003.
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Abruptio placentae and disseminated intravascular coagulopathy.胎盘早剥与弥散性血管内凝血
Semin Perinatol. 2009 Jun;33(3):189-95. doi: 10.1053/j.semperi.2009.02.005.
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[Alterations in coagulation and fibrinolytic system in abruptio placentae (author's transl)].胎盘早剥时凝血及纤溶系统的改变(作者译)
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Apr;34(4):529-37.
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[Heparin therapy in pregnancy toxemia a parallelism of the therapy for consumption coagulopathy?].[妊娠毒血症中的肝素疗法与消耗性凝血病的治疗平行吗?]
Dtsch Med Wochenschr. 1972 Mar 17;97(11):417-8 passim. doi: 10.1055/s-0028-1107368.
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Intrapartum anti-disseminated intravascular coagulation therapy leading to successful vaginal delivery following intrauterine fetal death caused by placental abruption: a case report.胎盘早剥致宫内死胎后,产时抗弥散性血管内凝血治疗成功实现阴道分娩:一例报告
J Med Case Rep. 2014 Dec 23;8:461. doi: 10.1186/1752-1947-8-461.
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Heparin treatment in abruptio placentae.胎盘早剥的肝素治疗
Can Med Assoc J. 1974 May 18;110(10):1159-64.
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Relevance of plasma fibrinogen estimation in obstetric complications.血浆纤维蛋白原测定在产科并发症中的相关性
J Postgrad Med. 1992 Oct-Dec;38(4):183-5.
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[Consumption coagulopathy during pregnancy: a case of afibrinogenemia during the second trimester].妊娠期消耗性凝血病:一例孕中期无纤维蛋白原血症病例
J Gynecol Obstet Biol Reprod (Paris). 1995;24(8):860-2.

引用本文的文献

1
Clinical application of inhibitors of fibrinolysis.纤维蛋白溶解抑制剂的临床应用。
Drugs. 1985 Mar;29(3):236-61. doi: 10.2165/00003495-198529030-00003.