Appell R A, England H R, Hussell A R, McGuire E J
J Urol. 1980 Sep;124(3):410-1. doi: 10.1016/s0022-5347(17)55474-9.
In 10 patients with obstructive manifestations of prostatic enlargement the urethral closure pressure profile was observed before and after the effective blockade of thoracolumbar sympathetic outflow by epidural anesthesia. While epidural anesthesia significantly decreased urethral closure pressure considerable profile responses still remained in these patients. This fact suggests that the bulk of the prostatic tissue is responsible for the bladder outlet obstruction, since urethral closure pressure persists despite urethral smooth and skeletal muscular relaxation as a result of epidural anesthesia. After transurethral resection of the prostatic tissue in these patients the urethral closure pressure did decrease to zero. The result of the prostatic resection is to decrease the urethral closure pressure and, thereby, increase the efficiency of voiding.
在10例有前列腺增生梗阻表现的患者中，通过硬膜外麻醉有效阻断胸腰段交感神经传出后，观察了尿道闭合压力曲线。虽然硬膜外麻醉显著降低了尿道闭合压力，但这些患者仍有相当大的曲线反应。这一事实表明，大部分前列腺组织是膀胱出口梗阻的原因，因为尽管硬膜外麻醉导致尿道平滑肌和骨骼肌松弛，但尿道闭合压力仍然持续存在。在这些患者经尿道切除前列腺组织后，尿道闭合压力确实降至零。前列腺切除的结果是降低尿道闭合压力，从而提高排尿效率。
