Metafora S, Felsani A, Cotrufo R, Tajana G F, Di Iorio G, Del Rio A, De Prisco P P, Esposito V
Proc R Soc Lond B Biol Sci. 1980 Aug 13;209(1175):239-55. doi: 10.1098/rspb.1980.0093.
Experiments are reported showing that following 8 days of denervation the function of the protein-synthesizing machinery, operating in the rat gastrocnemius fibres, is altered, probably as a consequence of decreased amounts of ribosomes and actively translated mRNA. In addition, the data obtained show that the amount per muscle and the availability per ribosome of the soluble factors involved in the process of protein synthesis are markedly decreased, thus suggesting that the amounts of ribosomes, mRNA and soluble factors are regulated in a concerted fashion when muscular protein synthesis is decreased after denervation.
有实验报告表明，在大鼠腓肠肌纤维中，去神经支配8天后，蛋白质合成机制的功能发生改变，这可能是核糖体数量减少和mRNA活跃翻译量减少的结果。此外，所获得的数据表明，参与蛋白质合成过程的可溶性因子的每块肌肉含量及其每个核糖体的可利用量均显著降低，这表明在去神经支配后肌肉蛋白质合成减少时，核糖体、mRNA和可溶性因子的量是以协同方式调节的。
