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大鼠肾上腺去神经支配显著增加前脑啡肽原信使核糖核酸。

Denervation of rat adrenal glands markedly increases preproenkephalin mRNA.

作者信息

Kilpatrick D L, Howells R D, Fleminger G, Udenfriend S

出版信息

Proc Natl Acad Sci U S A. 1984 Nov;81(22):7221-3. doi: 10.1073/pnas.81.22.7221.

DOI:10.1073/pnas.81.22.7221
PMID:6594691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC392110/
Abstract

The effect of denervation on the expression of rat adrenal proenkephalin has been examined. Following splanchnicectomy there was a several-fold increase in the steady-state levels of preproenkephalin mRNA, which became maximal after 24-48 hr (greater than 10-fold). These results indicate that the previously observed increase in rat adrenal enkephalin-containing peptides following denervation occurs entirely by a pretranslational mechanism. The increase in preproenkephalin mRNA was accompanied by a 50-75% decrease in rat adrenal poly(A)+ RNA. Neural input thus exerts a profound trophic influence on proenkephalin gene expression and RNA metabolism in rat adrenals.

摘要

已经研究了去神经支配对大鼠肾上腺前脑啡肽表达的影响。内脏神经切除术后，前脑啡肽原mRNA的稳态水平增加了几倍，在24 - 48小时后达到最大值（超过10倍）。这些结果表明，先前观察到的去神经支配后大鼠肾上腺中含脑啡肽肽类的增加完全是通过翻译前机制发生的。前脑啡肽原mRNA的增加伴随着大鼠肾上腺多聚腺苷酸加尾RNA减少50 - 75%。因此，神经输入对大鼠肾上腺中脑啡肽原基因表达和RNA代谢具有深远的营养影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b674/392110/dfb07d732c57/pnas00623-0321-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b674/392110/b7c6c4a87bbb/pnas00623-0321-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b674/392110/dfb07d732c57/pnas00623-0321-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b674/392110/b7c6c4a87bbb/pnas00623-0321-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b674/392110/dfb07d732c57/pnas00623-0321-b.jpg

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1
Denervation of rat adrenal glands markedly increases preproenkephalin mRNA.大鼠肾上腺去神经支配显著增加前脑啡肽原信使核糖核酸。
Proc Natl Acad Sci U S A. 1984 Nov;81(22):7221-3. doi: 10.1073/pnas.81.22.7221.
2
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本文引用的文献

1
Marked increases in large enkephalin-containing polypeptides in the rat adrenal gland following denervation.去神经支配后大鼠肾上腺中含大的脑啡肽的多肽显著增加。
J Neurosci. 1981 Jan;1(1):80-2. doi: 10.1523/JNEUROSCI.01-01-00080.1981.
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Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.细胞质斑点杂交。对多个小细胞或组织样本中相对mRNA水平的简单分析。
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Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.人甲硫氨酸脑啡肽和亮氨酸脑啡肽前体及其信使核糖核酸的一级结构。
完整的前脑啡肽是大鼠肾上腺去神经支配后产生的主要含脑啡肽肽。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7985-8. doi: 10.1073/pnas.81.24.7985.
4
Molecular cloning and sequence determination of rat preproenkephalin cDNA: sensitive probe for studying transcriptional changes in rat tissues.大鼠前脑啡肽原cDNA的分子克隆与序列测定：用于研究大鼠组织转录变化的灵敏探针。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7651-5. doi: 10.1073/pnas.81.23.7651.
5
Depolarization regulates adrenal preproenkephalin mRNA.去极化调节肾上腺前脑啡肽原信使核糖核酸。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8252-5. doi: 10.1073/pnas.82.23.8252.
6
Reflex splanchnic nerve stimulation increases levels of proenkephalin A mRNA and proenkephalin A-related peptides in the rat adrenal medulla.反射性内脏神经刺激可增加大鼠肾上腺髓质中前脑啡肽原A mRNA和前脑啡肽原A相关肽的水平。
Proc Natl Acad Sci U S A. 1986 Dec;83(23):9245-9. doi: 10.1073/pnas.83.23.9245.
7
The enkephalin-containing cell: strategies for polypeptide synthesis and secretion throughout the neuroendocrine system.含脑啡肽细胞：整个神经内分泌系统中多肽合成与分泌的策略
Cell Mol Neurobiol. 1987 Dec;7(4):339-52. doi: 10.1007/BF00733787.
8
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Activity-dependent regulation of gene expression in muscle and neuronal cells.肌肉和神经细胞中基因表达的活性依赖性调控。
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EMBO J. 1986 May;5(5):967-70. doi: 10.1002/j.1460-2075.1986.tb04310.x.
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4
Appearance of enkephalin-immunoreactivity in rat adrenal medulla following treatment with nicotinic antagonists or reserpine.用烟碱拮抗剂或利血平处理后大鼠肾上腺髓质中脑啡肽免疫反应性的出现情况。
Cell Tissue Res. 1983;231(3):469-79. doi: 10.1007/BF00218106.
5
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Proc Natl Acad Sci U S A. 1984 Jun;81(11):3587-90. doi: 10.1073/pnas.81.11.3587.
6
Denervated skeletal muscle displays discoordinate regulation for the synthesis of several myofibrillar proteins.失神经支配的骨骼肌对几种肌原纤维蛋白的合成表现出不协调的调节。
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Regulation of apolipoprotein A1 synthesis in avian muscles.禽类肌肉中载脂蛋白A1合成的调控。
J Biol Chem. 1983 Dec 25;258(24):14829-33.
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A sensitive fluorometric assay for the determination of DNA.一种用于测定DNA的灵敏荧光测定法。
Anal Biochem. 1982 Mar 1;120(2):243-8. doi: 10.1016/0003-2697(82)90342-6.
9
Neural control of gene expression in the skeletal muscle fibre: the nature of the lesion in the muscular protein-synthesizing machinery following denervation.骨骼肌纤维中基因表达的神经控制：去神经支配后肌肉蛋白质合成机制中的损伤性质。
Proc R Soc Lond B Biol Sci. 1980 Aug 13;209(1175):239-55. doi: 10.1098/rspb.1980.0093.
10
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.变性RNA与转移至硝酸纤维素膜上的小DNA片段的杂交。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5. doi: 10.1073/pnas.77.9.5201.