Clausing P, Gottschalk M, Mahro U, Bleyl D W, Karg G
Arch Exp Veterinarmed. 1980;34(3):405-16.
Doses of 50 mg/kg, 100 mg/kg, and 400 mg/kg of Gamma-Falisan-Universal dry dressing agent (active ingredients including 20 per cent of Lindan and 2.5 per cent of phenyl-mercury acetate) were administered in agar suspension by stomach intubation to rats over 13 weeks, with five applications weekly. The following changes were produced: retardation in body weight, lymphopenia and leucopenia, rise of segment-nuclear neutrophils in peripheral blood, decrease of haematocrit and haemoglobin, as well as rise in activities of leucine aminopeptidase and serum glutamate oxalo-acetate transaminase. The males proved to be more sensitive in the context of their haematological parameters, while the females displayed higher sensitivity in terms of clinico-chemical values. Absolute weight increases were recorded from kidneys and liver of both males and females and from the adrenal gland of females, while weight loss was recorded from the pituitary gland of males. Changes of the same kind were expressed even more strongly, in the context of relative weights of organs. Histopathological changes were recorded from liver, kidneys, and adrenal gland of either sex, and they were histometrically confirmed. Retardation in body weight, rise in activity of leucine aminopeptidase, and weight changes of various organs were significant up to first dosage group. Analogous findings were obtained with regard to microscopic changes in kidneys. Hence, no-effect levels did not occur at all throughout the experiment.
将50毫克/千克、100毫克/千克和400毫克/千克的伽马 - 法利桑通用干敷料剂（活性成分包括20%的林丹和2.5%的醋酸苯汞）以琼脂悬浮液的形式通过胃插管每周给药5次，持续13周给予大鼠。产生了以下变化：体重增长迟缓、淋巴细胞减少和白细胞减少、外周血分叶核中性粒细胞增多、红细胞压积和血红蛋白降低，以及亮氨酸氨基肽酶和血清谷氨酸草酰乙酸转氨酶活性升高。在血液学参数方面，雄性大鼠表现得更为敏感，而在临床化学值方面，雌性大鼠表现出更高的敏感性。雄性和雌性大鼠的肾脏和肝脏以及雌性大鼠的肾上腺绝对重量增加，而雄性大鼠的垂体重量减轻。在器官相对重量方面，同样类型的变化表现得更为明显。在雄性和雌性大鼠的肝脏、肾脏和肾上腺均记录到组织病理学变化，并通过组织计量学得到证实。直至第一个剂量组，体重增长迟缓、亮氨酸氨基肽酶活性升高以及各器官重量变化均具有显著性。在肾脏的微观变化方面也获得了类似的结果。因此，在整个实验过程中根本未出现无效应水平。
