Thiéry J P, Ovtracht L
C R Seances Soc Biol Fil. 1980;174(4):584-97.
The ultrastructural chemistry on isolated macromolecules enables to localize chemical function on spread molecules by means of reactions whose product is visible in electron microscopy (metal colloids, lectins, etc.). The reaction of linear polyanions with metachromatic dyes (bifunctional ligands) results in the formation of metachromatic complexes with a periodic structure : ligand molecules are intercalated between the polyanions arranged in parallel arrays; this structure is correlated with the metachromasy.
对分离出的大分子进行超微结构化学研究，能够通过其产物在电子显微镜下可见的反应（金属胶体、凝集素等）来确定分散分子上的化学功能。线性聚阴离子与异染性染料（双功能配体）的反应会形成具有周期性结构的异染性复合物：配体分子插入平行排列的聚阴离子之间；这种结构与异染现象相关。
