组胺H2受体拮抗剂在卓-艾综合征患者治疗中的价值。
The value of a histamine H2-receptor antagonist in the management of patients with the Zollinger-Ellison syndrome.
作者信息
Richardson C T, Walsh J H
出版信息
N Engl J Med. 1976 Jan 15;294(3):133-5. doi: 10.1056/NEJM197601152940304.
Inhibition of acid secretion by an H2-receptor antagonist (metiamide) was assessed in three patients with the Zollinger-Ellison syndrome. Metiamide (200 or 300 mg) inhibited acid secretion transiently (2 1/2 hours) by 85 to 100 per cent in all patients. Although anticholinergic drugs alone inhibited acid secretion by only 0 to 35 per cent in these patients, the combination of metiamide and anticholinergic markedly prolonged the inhibitory effect of metiamide. Total gastrectomy was refused by one patient, and was impossible in another; both were treated with metiamide and anticholinergic for five and 10 months. A third patient was treated with metiamide and anticholinergic for three weeks in preparation for total gastrectomy. Ulcer pain and diarrhea disappeared, and each gained weight. H2-receptor antagonists may be useful in the treatment of some patients with the Zollinger-Ellison syndrome.
在三名佐林格-埃利森综合征患者中评估了H2受体拮抗剂（甲硫米特）对胃酸分泌的抑制作用。甲硫米特（200或300毫克）在所有患者中均能短暂（2个半小时）抑制胃酸分泌85%至100%。尽管单独使用抗胆碱能药物在这些患者中仅能抑制胃酸分泌0%至35%，但甲硫米特与抗胆碱能药物联合使用显著延长了甲硫米特的抑制作用。一名患者拒绝接受全胃切除术，另一名患者无法进行该手术；这两名患者均接受了甲硫米特和抗胆碱能药物治疗，分别治疗了5个月和10个月。第三名患者在准备进行全胃切除术时接受了甲硫米特和抗胆碱能药物治疗3周。溃疡疼痛和腹泻消失，且每名患者体重均增加。H2受体拮抗剂可能对某些佐林格-埃利森综合征患者的治疗有用。
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