创伤、右旋糖酐1000及右旋糖酐40对循环肿瘤细胞黏附的影响
The influence of trauma, Dextran 1000, and Dextran 40 on the lodgement of circulating tumor cells.
作者信息
Skolnik G, Alpsten M, Ivarsson L
出版信息
J Cancer Res Clin Oncol. 1980;97(3):241-8. doi: 10.1007/BF00405775.
Abstract
Earlier studies have shown that trauma and infusion of Dextran 1000 increased the formation of pulmonary metastases after i.v. tumor cell injection in rats. Infusion of Dextran 40 enhanced the pulmonary metastasis formation in traumatized but not in non-traumatized animals. In this study tumor cells labelled with a radioactive isotope were used to register the lodgement circulating tumor cells after trauma and infusion of Dextran 1000 and Dextran 40. It was found that the pulmonary lodgement of tumor cells was increased after trauma and infusion of Dextran 1000. Dextran 40 did not influence the lodgement in a significant way either in normal or in traumatized animals. Thus, the increased formation of metastases after trauma and infusion of Dextran 1000 seems to depend upon an increased tumor cell lodgement.
摘要
早期研究表明，在大鼠静脉注射肿瘤细胞后，创伤和输注右旋糖酐1000会增加肺转移的形成。输注右旋糖酐40可增强受创伤动物而非未受创伤动物的肺转移形成。在本研究中，用放射性同位素标记的肿瘤细胞用于记录创伤以及输注右旋糖酐1000和右旋糖酐40后循环肿瘤细胞的着床情况。结果发现，创伤和输注右旋糖酐1000后肿瘤细胞在肺中的着床增加。右旋糖酐40在正常动物或受创伤动物中均未对着床产生显著影响。因此，创伤和输注右旋糖酐1000后转移形成增加似乎取决于肿瘤细胞着床的增加。
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