Wagener C, Breuer H
J Clin Chem Clin Biochem. 1980 Nov;18(11):821-7.
A workshop conference was held on the diagnostic significance of tumour markers in clinical chemistry. The aims of the conference were (1) discussion of the methodological prerequisites for the standardization of tumour marker determinations, and (2) description of those clinical conditions under which the determination of tumour markers should be carried out. The following aspects were discussed in detail: Sampling, comparison of different methods, standardization and quality control, and pathobiochemical aspects. As far as clinical aspects were concerned, emphasis was laid upon the following points: Screening and limits of early diagnosis, evaluation of tumour growth, prognosis, follow-up studies. In addition to oncofetal tumour proteins, hormones, enzymes, and placental proteins were also discussed.
举办了一次关于肿瘤标志物在临床化学中诊断意义的研讨会。该研讨会的目的是:(1)讨论肿瘤标志物测定标准化的方法学前提条件;(2)描述应进行肿瘤标志物测定的临床情况。详细讨论了以下方面:采样、不同方法的比较、标准化与质量控制以及病理生物化学方面。就临床方面而言,重点强调了以下几点:筛查与早期诊断的局限性、肿瘤生长评估、预后、随访研究。除了癌胚肿瘤蛋白外,还讨论了激素、酶和胎盘蛋白。