Watson R D, Eriksson B M, Hamilton C A, Reid J L, Stallard T J, Littler W A
J Cardiovasc Pharmacol. 1980 Nov-Dec;2(6):725-38. doi: 10.1097/00005344-198011000-00003.
Plasma catecholamines were measured before and after treatment with beta-adrenoceptor antagonists in 17 hypertensive patients. Chronic treatment with beta-adrenoceptor antagonists caused substantial reductions in heart rate and intra-arterial blood pressure recorded continuously during ambulation. Before treatment, a quantitative relationship was observed between plasma norepinephrine and blood pressure and heart rate during a variety of activities; a similar relationship was also observed after chronic treatment five of six patients, suggesting that plasma norepinephrine remains an index of sympathetic activity despite the influence of beta-adrenoceptor antagonism. After treatment, plasma norepinephrine tended to be higher at any level of blood pressure, although not significantly so. Chronic treatment caused no significant change in mean resting plasma levels of norepinephrine and epinephrine. During exercise, plasma norepinephrine and epinephrine levels were significantly elevated above control after acute but not after chronic treatment. These observations do not support the hypothesis that beta-adrenoceptor antagonist drugs lower blood pressure in hypertensive man through a sympatholytic mechanism in he central nervous system or at peripheral presynaptic receptors.
对17例高血压患者在使用β-肾上腺素能受体拮抗剂治疗前后测定了血浆儿茶酚胺水平。β-肾上腺素能受体拮抗剂的长期治疗使患者在行走过程中持续记录的心率和动脉内血压大幅降低。治疗前，在各种活动期间观察到血浆去甲肾上腺素与血压和心率之间存在定量关系；在6例患者中的5例经过长期治疗后也观察到了类似关系，这表明尽管受到β-肾上腺素能受体拮抗作用的影响，血浆去甲肾上腺素仍然是交感神经活动的一个指标。治疗后，在任何血压水平下，血浆去甲肾上腺素往往都较高，尽管差异不显著。长期治疗并未使去甲肾上腺素和肾上腺素的平均静息血浆水平发生显著变化。在运动期间，急性治疗后血浆去甲肾上腺素和肾上腺素水平显著高于对照水平，但长期治疗后则不然。这些观察结果不支持以下假设，即β-肾上腺素能受体拮抗剂药物通过中枢神经系统或外周突触前受体的交感神经阻滞机制降低高血压患者的血压。
