Salt T E, Hill R G
Neurosci Lett. 1980 Dec;20(3):329-34. doi: 10.1016/0304-3940(80)90169-x.
Microiontophoretically applied capsaicin (10-480 nA) excited neurones in trigeminal nucleus caudalis (ntV) or potentiated their amino acid-induced excitation (20 of 23 neurones); inhibited one neurone; and had no effect on 2 neurones. Substance P (SP) excited 8 of 9 ntV neurones, and of these 8 neurones 6 were excited, one was depressed, and one was unaffected by capsaicin. Of 13 cerebellar neurones, 5 were depressed by capsaicin and 8 were unaffected. SP excited 3 of 5 cerebellar neurones. It is concluded that the excitatory action of capsaicin in ntV may be due to release of SP from neuronal structures and that the lack of excitatory effects seen in the cerebellum may reflect the absence of SP-containing neurones in this structure.
微量离子透入法施加的辣椒素（10 - 480纳安）可兴奋三叉神经尾侧核（ntV）中的神经元，或增强其由氨基酸诱导的兴奋作用（23个神经元中有20个）；抑制了1个神经元；对2个神经元无影响。P物质（SP）兴奋了9个ntV神经元中的8个，在这8个神经元中，6个被辣椒素兴奋，1个被抑制，1个不受辣椒素影响。在13个小脑神经元中，5个被辣椒素抑制，8个不受影响。SP兴奋了5个小脑神经元中的3个。得出的结论是，辣椒素在ntV中的兴奋作用可能是由于从神经元结构中释放了SP，而在小脑中未观察到兴奋作用可能反映了该结构中不含SP的神经元的缺失。
