Riederer P, Jellinger K, Kleinberger G, Weiser M
Nutr Metab. 1980;24(4):209-17. doi: 10.1159/000176343.
The intravenous application of the branched chain amino acid L-valine to patients with hepatic coma resulted in a specific drop of tryptophan, serotonin and 5-hydroxyindole acetic acid. Clinical improvement of hepatic encephalopathy and of the underlying neurotransmitter (serotonin) and ammonia derangements by administration of L-valine suggest a possible role of this competitive amino acid on intermediary metabolism and ammonia detoxification.
对肝昏迷患者静脉输注支链氨基酸L-缬氨酸，可使色氨酸、5-羟色胺和5-羟吲哚乙酸显著下降。给予L-缬氨酸后肝性脑病以及潜在的神经递质（5-羟色胺）和氨代谢紊乱得到临床改善，提示这种竞争性氨基酸在中间代谢和氨解毒过程中可能发挥作用。
