N-2-芴基乙酰胺诱导肝癌发生过程中α-甲胎蛋白的合成及其与致癌物细胞内定位的关系
On the synthesis of alpha-fetoprotein during liver carcinogenesis by N-2-fluorenylacetamide and its relationships with the intracellular localization of the carcinogen.
作者信息
Stora C, Aussel C, Lafaurie M, Krebs B, Ayraud N
出版信息
Oncology. 1981;38(1):43-6. doi: 10.1159/000225520.
PMID:6160441
Abstract
Adult female Sprague-Dawley rats fed with 0.06% N-2-fluorenylacetamide presented an augmentation of plasma alpha-fetoprotein 2 days after the beginning of the experiment. This very early synthesis of alpha-fetoprotein was concomitant with the penetration of N-2-fluorenylacetamide detected by fluorescence microscopy, in the cytoplasm of the hepatocytes.
摘要
用0.06%的N-2-芴基乙酰胺喂养的成年雌性Sprague-Dawley大鼠在实验开始2天后血浆甲胎蛋白增加。甲胎蛋白的这种非常早期的合成与通过荧光显微镜检测到的N-2-芴基乙酰胺在肝细胞细胞质中的渗透同时发生。
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