甲胎蛋白（AFP）在肝癌发生及出生后发育过程中对卵巢活动的调节作用。

Role of alpha-fetoprotein (AFP) in the regulation of ovarian activity during hepatocarcinogenesis and post-natal development.

作者信息

Aussel C, Castelli D, La Faurie M, Krebs B, Ayraud N, Stora C, Masseyeff R

出版信息

Oncodev Biol Med. 1982;3(1):65-71.

Abstract

N-fluorenylacetamide produces an augmentation of serum AFP which is accompanied by a drastic decrease of ovarian activity. A passive augmentation of the AFP level of adult rats, produced by injection of this protein provokes the same phenomenon: i.e. a decrease of follicular maturation, a decrease number of corpora lutea and finally a drop in the plasma progesterone level. The study of ovarian post-natal development shows that ovarian maturity occurs on the 35th day of life when AFP level reaches its adult serum concentration. These facts support the hypothesis that AFP plays a role in the regulation of ovaries during the sexual maturation of the female rat.

摘要

N-芴基乙酰胺会使血清甲胎蛋白增加，同时卵巢活动急剧下降。通过注射这种蛋白质使成年大鼠甲胎蛋白水平被动增加也会引发同样的现象，即卵泡成熟减少、黄体数量减少，最终血浆孕酮水平下降。对卵巢产后发育的研究表明，当甲胎蛋白水平达到成年血清浓度时，卵巢在出生后第35天成熟。这些事实支持了甲胎蛋白在雌性大鼠性成熟过程中对卵巢调节起作用的假说。