Blalock J E, Smith E M
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5972-4. doi: 10.1073/pnas.77.10.5972.
Anti-alpha-corticotropin [anti-ACTH alpha (1-13)](also alpha-melanotropin) and anti-gamma-endorphin antisera neutralized human leukocyte interferon activity but not fibroblast interferon activity. Human leukocyte interferon was not neutralized by anti-human lutenizing hormone (lutropin) or follicle-stimulating hormone (follitropin) antisra. Conversely, antisera to human leukocyte interferon neutralized ACTH activity. The neturalization of human leukocyte interferon by anti-human leukocyte interferon serum was partially blocked by ACTH. These studies show strong antigenic relatedness among human leukocyte interferon, ACTH, and endorphins, implying that there are underlying structural similarities. Structural relatedness is shown by pepsin cleavage of ACTH activity from human leukocyte interferon. The implication for the natural functions of human leukocyte interferon are discussed.
抗α-促肾上腺皮质激素抗促肾上腺皮质激素α(1 - 13)和抗γ-内啡肽抗血清可中和人白细胞干扰素活性，但不能中和成纤维细胞干扰素活性。人白细胞干扰素不会被抗人促黄体生成素(促性腺激素)或促卵泡激素(促卵泡素)抗血清所中和。相反，人白细胞干扰素抗血清可中和促肾上腺皮质激素活性。抗人白细胞干扰素血清对人白细胞干扰素的中和作用被促肾上腺皮质激素部分阻断。这些研究表明人白细胞干扰素、促肾上腺皮质激素和内啡肽之间存在很强的抗原相关性，这意味着它们在潜在结构上存在相似性。胃蛋白酶从人白细胞干扰素中切割出促肾上腺皮质激素活性，这表明了结构相关性。文中还讨论了人白细胞干扰素自然功能的相关意义。
