人白细胞干扰素：与促肾上腺皮质激素及内啡肽的结构和生物学相关性
Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.
作者信息
Blalock J E, Smith E M
出版信息
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5972-4. doi: 10.1073/pnas.77.10.5972.
Abstract
Anti-alpha-corticotropin [anti-ACTH alpha (1-13)](also alpha-melanotropin) and anti-gamma-endorphin antisera neutralized human leukocyte interferon activity but not fibroblast interferon activity. Human leukocyte interferon was not neutralized by anti-human lutenizing hormone (lutropin) or follicle-stimulating hormone (follitropin) antisra. Conversely, antisera to human leukocyte interferon neutralized ACTH activity. The neturalization of human leukocyte interferon by anti-human leukocyte interferon serum was partially blocked by ACTH. These studies show strong antigenic relatedness among human leukocyte interferon, ACTH, and endorphins, implying that there are underlying structural similarities. Structural relatedness is shown by pepsin cleavage of ACTH activity from human leukocyte interferon. The implication for the natural functions of human leukocyte interferon are discussed.
摘要
抗α-促肾上腺皮质激素抗促肾上腺皮质激素α(1 - 13)和抗γ-内啡肽抗血清可中和人白细胞干扰素活性，但不能中和成纤维细胞干扰素活性。人白细胞干扰素不会被抗人促黄体生成素(促性腺激素)或促卵泡激素(促卵泡素)抗血清所中和。相反，人白细胞干扰素抗血清可中和促肾上腺皮质激素活性。抗人白细胞干扰素血清对人白细胞干扰素的中和作用被促肾上腺皮质激素部分阻断。这些研究表明人白细胞干扰素、促肾上腺皮质激素和内啡肽之间存在很强的抗原相关性，这意味着它们在潜在结构上存在相似性。胃蛋白酶从人白细胞干扰素中切割出促肾上腺皮质激素活性，这表明了结构相关性。文中还讨论了人白细胞干扰素自然功能的相关意义。
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本文引用的文献
1
Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds.通过二硫键还原从二价兔抗体分子中分离单价片段。
Arch Biochem Biophys. 1960 Aug;89:230-44. doi: 10.1016/0003-9861(60)90049-7.
2
Hormone-producing cultures of adrenal and pituitary tumor origin.源自肾上腺和垂体肿瘤的激素分泌培养物。
Proc Natl Acad Sci U S A. 1962 Jul 15;48(7):1184-90. doi: 10.1073/pnas.48.7.1184.
3
Virus interference. I. The interferon.病毒干扰。一、干扰素。
Proc R Soc Lond B Biol Sci. 1957 Sep 12;147(927):258-67. doi: 10.1098/rspb.1957.0048.
4
Amino terminal sequence of the major component of human lymphoblastoid interferon.人淋巴母细胞样干扰素主要成分的氨基末端序列。
Science. 1980 Feb 1;207(4430):527-8. doi: 10.1126/science.7352260.
5
Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence.人成纤维细胞干扰素：氨基酸分析及氨基末端氨基酸序列
Science. 1980 Feb 1;207(4430):525-6. doi: 10.1126/science.7352259.
6
Common pathways of interferon and hormonal action.干扰素与激素作用的共同途径。
Nature. 1980 Jan 24;283(5745):406-8. doi: 10.1038/283406a0.
7
Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferon.纯化的人免疫干扰素比成纤维细胞干扰素或白细胞干扰素具有更强的抗细胞活性。
Cell Immunol. 1980 Feb;49(2):390-4. doi: 10.1016/0008-8749(80)90041-6.
8
Role of receptors and the cytoskeleton in reverse transformation and steroidogenesis induced by interferon.受体和细胞骨架在干扰素诱导的逆向转化和类固醇生成中的作用。
Ann N Y Acad Sci. 1980;350:254-65. doi: 10.1111/j.1749-6632.1980.tb20626.x.
9
Stimulation of steroidogenesis in tissue culture by enterotoxigenic Escherichia coli and its neutralization by specific antiserum.产肠毒素大肠杆菌对组织培养中类固醇生成的刺激作用及其被特异性抗血清的中和作用。
Infect Immun. 1974 Mar;9(3):500-5. doi: 10.1128/iai.9.3.500-505.1974.
10
Antitumor effects of interferon.干扰素的抗肿瘤作用。
Biochim Biophys Acta. 1978 Oct 27;516(2):231-47. doi: 10.1016/0304-419x(78)90009-4.
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