[Effect of hypokinesia on nucleic acid and protein metabolism in the lymphoid organs of rats].
作者信息
Komolova G S
出版信息
Biull Eksp Biol Med. 1980 Nov;90(11):548-50.
PMID:6160884
Abstract
Metabolism of nucleic acids and protein by lymphoid cells of the rat spleen and thymus was studied under conditions of 22-day hypokinesia. It was shown that in the course of hypokinesia the loss of cellular mass by the spleen and thymus was associated with varied biochemical changes in the remaining lymphoid cells. The thymocytes showed a significant activation of nucleic acid and protein biosynthesis. Meanwhile in spleen lymphocytes, DNA and RNA metabolism was inhibited with no appreciable changes in protein metabolism. Potential mechanisms of changes in metabolism of thymus and spleen lymphocytes under long-term hypokinesia are discussed.
摘要
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