Misurova E, Kropacova K
Institute of General Biology, P.J. Safarik University, Kosice, Czechoslovakia.
Acta Astronaut. 1991 Aug-Sep;25(8-9):587-89.
The quantitative changes in nucleic acids and chromatin breakdown were followed in blood, thymus and spleen in rats after 14 day flights on board the biosatellites Cosmos-1887 and Cosmos-2044. Quantitative nucleic acid changes within 8-11 h after landing were only mild, most statistically non-significant. An analysis at 48 h after landing showed a marked decrease in a total content of DNA and RNA in spleen and thymus. Within 8-11 h after landing, the symptoms of chromatin breakdown were found as is seen in an increased concentration of its fragments-polydeoxyribonucleotides. The obtained results show that a partial adaptation to microgravity occurs up to flight day 14 in lymphoid organs. Adaptation is accompanied with a reappearing of the sensitive cells. Their chromatin breaks down, then, in a final phase of flight due to hypergravity stress manifesting itself by a temporary increase in polydeoxyribonucleotide concentration several hours after landing. The results are discussed in relation to the changes in chosen parameters after shorter or more prolonged flights.
在“宇宙-1887号”和“宇宙-2044号”生物卫星上飞行14天后，对大鼠血液、胸腺和脾脏中核酸和染色质分解的定量变化进行了跟踪研究。着陆后8 - 11小时内核酸的定量变化仅为轻微变化，大多数在统计学上无显著意义。着陆后48小时的分析显示，脾脏和胸腺中DNA和RNA的总含量显著下降。着陆后8 - 11小时内，发现了染色质分解的症状，表现为其片段——多脱氧核糖核苷酸浓度的增加。所得结果表明，在飞行第14天之前，淋巴器官会出现对微重力的部分适应。适应过程伴随着敏感细胞的重新出现。它们的染色质会分解，然后在飞行的最后阶段，由于着陆后数小时内多脱氧核糖核苷酸浓度暂时升高所表现出的超重应激而分解。结合较短或较长飞行后所选参数的变化对结果进行了讨论。
