Umapathysivam K, Jones W R
Contraception. 1980 Oct;22(4):425-40. doi: 10.1016/0010-7824(80)90027-x.
An analysis of the nucleic acid and protein composition of endometrial tissue was undertaken in normal women and in patients using either steroidal oral contraceptives or intrauterine contraceptive devices (IUCD). In the presence of an IUCD, endometrial RNA/DNA and protein/DNA ratios were elevated in the secretory phase of the menstrual cycle compared to values obtained in normal women. In the oral contraceptive group, endometrial RNA/DNA and protein/DNA ratios were below the normal range in the late proliferative phase of the cycle. Typical electrophoretic profiles in the oral contraceptive group were similar to the control group, although a quantitative analysis revealed that the concentrations of certain characteristic uterine proteins were reduced. In the IUCD group, there was a preferential appearance of two proteins with approximate molecular weights of 36,000 and 26,000 daltons. Another protein with a molecular weight of 48,000 daltons, which demonstrated a cyclic change during the normal menstrual cycle, was reduced in both study groups. The results suggest that both agents studied induce changes in the macromolecular composition of the human endometrium which may relate to their contraceptive effect.
对正常女性以及使用甾体类口服避孕药或宫内节育器（IUCD）的患者的子宫内膜组织进行了核酸和蛋白质组成分析。在使用IUCD的情况下，与正常女性相比，月经周期分泌期子宫内膜的RNA/DNA和蛋白质/DNA比值升高。在口服避孕药组中，周期增殖晚期子宫内膜的RNA/DNA和蛋白质/DNA比值低于正常范围。口服避孕药组典型的电泳图谱与对照组相似，尽管定量分析显示某些特征性子宫蛋白的浓度降低。在IUCD组中，优先出现了两种分子量约为36,000和26,000道尔顿的蛋白质。另一种分子量为48,000道尔顿的蛋白质，在正常月经周期中呈现周期性变化，在两个研究组中均减少。结果表明，所研究的两种药物均会引起人子宫内膜大分子组成的变化，这可能与其避孕效果有关。
