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钙依赖分泌激活的早期事件：大鼠腹膜肥大细胞的研究

Early events in the activation of Ca2+ dependent secretion: studies with rat peritoneal mast cells.

作者信息

Gomperts B D, Cockcroft S, Bennett J P, Fewtrell C M

出版信息

J Physiol (Paris). 1980 Sep;76(5):383-93.

PMID:6161245
Abstract
  1. Secretion of histamine from mast cells is a Ca2+ dependent exocytotic process initiated by attachment of various agents to receptors on the cell surface. Secretion can also be triggered by the Ca2+ ionophores A23187 and ionomycin. Only in the case of the ionophores is the mechanism of Ca2+ mobilisation understood. 2. When agonist ligands are added to cells which have been preincubated with 32P-phosphate or 3H-inositol, one can detect an increase in the rate of labeling of phosphatidylinositol. As for other systems, the phosphatidylinositol response in mast cells shows the characteristics of an early receptor directed event. 3. We discuss the relationship of the phosphatidylinositol response and Ca2+ mobilisation in mast cell activation.
摘要
  1. 肥大细胞分泌组胺是一个依赖Ca2+的胞吐过程，由各种试剂附着于细胞表面受体引发。分泌也可由Ca2+离子载体A23187和离子霉素触发。只有在离子载体的情况下，Ca2+动员的机制才被理解。2. 当将激动剂配体添加到预先用32P-磷酸盐或3H-肌醇预孵育的细胞中时，可以检测到磷脂酰肌醇标记率的增加。与其他系统一样，肥大细胞中的磷脂酰肌醇反应显示出早期受体导向事件的特征。3. 我们讨论了肥大细胞激活中磷脂酰肌醇反应与Ca2+动员的关系。

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