Weisburger E K
Mol Cell Biochem. 1980 Sep 15;32(2):95-104. doi: 10.1007/BF00227802.
A great deal of effort has gone into research on the mechanisms of action of chemical carcinogens. The action of the host on the carcinogen represents one approach--to determine what metabolic products may be involved. Study of the action of the carcinogen on the host requires a thorough comparison of changes wrought in cellular constituents by the carcinogen. Meshing of these two approaches increases the potential to discover the detailed mechanisms involved. Despite the increase in knowledge, many crucial molecular events and their consequences in the process of carcinogenesis still remain a mystery.
人们在化学致癌物作用机制的研究上投入了大量精力。宿主对致癌物的作用是一种研究途径——确定可能涉及哪些代谢产物。研究致癌物对宿主的作用需要对致癌物引起的细胞成分变化进行全面比较。将这两种方法结合起来，增加了发现所涉及详细机制的可能性。尽管知识有所增加，但致癌过程中许多关键的分子事件及其后果仍然是个谜。
