Oxford J S, Schild G C
NIPH Ann. 1980 May;3(1):39-48.
This paper reviews the current state of knowledge as regards the antigenic and biochemical heterogeneity of influenza viruses. It deals particularly with the influenza A virus, which has the unique features of changing antigenic structure and various factors related to virulence. These properties cause widespread epidemics at unpredictable intervals and give rise to concern among vaccine manufacturers and epidemiologists in the health services, but also provide biochemists and geneticists with a fascinating model for basic biological research. The present-day epidemiological situation with two influenza A subtypes circulating simultaneously is described.
本文综述了目前关于流感病毒抗原性和生化异质性的知识现状。它特别关注甲型流感病毒，该病毒具有抗原结构变化以及与毒力相关的各种因素等独特特征。这些特性导致每隔一段无法预测的时间就会出现广泛的流行，引发了疫苗制造商和卫生服务领域流行病学家的担忧，但同时也为生物化学家和遗传学家提供了一个用于基础生物学研究的迷人模型。文中描述了当前两种甲型流感病毒亚型同时传播的流行病学情况。
