Gendon Iu Z
Mol Gen Mikrobiol Virusol. 1985 Aug(8):3-12.
The data from literature and authors own studies are reviewed on variability of human influenza viral strains, isolated during the same epidemic season in different periods of pandemic cycle. The data obtained indicate that variability of epidemic strains of human influenza virus deals with the genes coding for outer membrane proteins (hemagglutinin and neuraminidase) as well as nonglycosylated proteins. Circulation of a number of viral variants of the same serotype, differing in antigenic specificity of outer membrane proteins or in the genes coding for nonglycosylated proteins was registered during one and the same season of one epidemic. During circulation of viral variants of the same serotype recombination may take place. Heterogeneity of viral strains circulating during different epidemic seasons of the same pandemic cycle is different. The possible mechanisms of development of the new epidemic variants of human influenza virus are discussed.
本文回顾了文献数据以及作者自身的研究，内容涉及在大流行周期不同阶段的同一流行季节中分离出的人类流感病毒株的变异性。所获得的数据表明，人类流感病毒流行株的变异性与编码外膜蛋白（血凝素和神经氨酸酶）以及非糖基化蛋白的基因有关。在同一流行季节中，记录到了同一血清型的多种病毒变体的传播，这些变体在外膜蛋白的抗原特异性或编码非糖基化蛋白的基因方面存在差异。在同一血清型病毒变体的传播过程中可能会发生重组。在同一大流行周期的不同流行季节中传播的病毒株的异质性是不同的。本文还讨论了人类流感病毒新流行变体产生的可能机制。
