胰岛素与前列腺素E1对刺激脂肪分解的协同作用。

Synergic effect of insulin and prostaglandin E1 on stimulated lipolysis.

Lambert B, Jacquemin C

Prostaglandins Med. 1980 Nov;5(5):375-82. doi: 10.1016/0161-4630(80)90109-3.

Abstract

The inhibitory effect of prostaglandin E1 on free fatty acid release from adipose tissue is significantly greater when the lipolysis is stimulated by 1-methyl-3-isobutyl xanthine than when stimulated by adrenaline. 2. The antilipolytic effect of insulin on adrenaline and 1-methyl-3-isobutyl xanthine stimulated lipolysis, is suppressed in the presence of inhibitors of prostaglandin synthetase i.e. indomethacin or phenelzine. 3. In the presence of phenelzine, the lack of effect of insulin on adrenaline and 1-methyl-3-isobutyl xanthine lipolysis is overcome by a small amount of prostaglandin E1 (10(-10)M) but not of prostaglandin F2 alpha. 4. The addition of prostaglandin E1 (10(-10)M) restores the inhibitory effect of insulin on cyclic AMP accumulation.

摘要

当脂解作用由1-甲基-3-异丁基黄嘌呤刺激时，前列腺素E1对脂肪组织游离脂肪酸释放的抑制作用比由肾上腺素刺激时显著更强。2. 在存在前列腺素合成酶抑制剂即吲哚美辛或苯乙肼的情况下，胰岛素对肾上腺素和1-甲基-3-异丁基黄嘌呤刺激的脂解作用的抗脂解效应受到抑制。3. 在存在苯乙肼的情况下，少量前列腺素E1（10⁻¹⁰M）可克服胰岛素对肾上腺素和1-甲基-3-异丁基黄嘌呤脂解作用的无效，但前列腺素F2α则不能。4. 添加前列腺素E1（10⁻¹⁰M）可恢复胰岛素对环磷酸腺苷积累的抑制作用。