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围产医学中α-甲胎蛋白的定量测定。第二篇通讯:验证新生儿脐带血中AFP浓度作为评估孕周的客观参数(作者译)

[Quantitative determination of alpha-foetoprotein in perinatal medicine. Second communication: Verification of AFP concentration in umbilical cord blood of newborns as an objective parameter for assessment of gestational age (author's transl)].

作者信息

Zlanabitnig H P, Landschek P, Geserick G, Lignitz E, Patzelt D

出版信息

Zentralbl Gynakol. 1980;102(16):897-908.

PMID:6161499
Abstract

AFP concentrations were recorded from umbilical cord serum of 482 newborns, with 453 of them weighing more than 2.500 gram and 29 less than 2,501 gram. The AFP values thus found were correlated with the established clinical parameters of gestation, such as birth weight, length, circumference of head, biparietal skull diameter, circumference of chest, and gestationsal age by case history. - The closest correlation between any two of the above selected clinical parameters was found to exist between AFP concentration and gestational age by case history, whereas correlations were least close between AFP and biparietal diameter. Measurement of AFP in umbilical cord blood is considered to be merely a complementary criterion for assessment of gestational age by clinical parameter, because of too large scatter of individual data.

摘要

记录了482名新生儿脐带血清中的甲胎蛋白(AFP)浓度,其中453名新生儿体重超过2500克,29名新生儿体重不足2501克。通过病史,将由此得出的AFP值与既定的妊娠临床参数相关联,如出生体重、身长、头围、双顶径、胸围和孕周。发现上述所选临床参数中,AFP浓度与病史孕周之间的相关性最为密切,而AFP与双顶径之间的相关性最不密切。由于个体数据的离散度太大,脐带血中AFP的测量仅被视为通过临床参数评估孕周的补充标准。

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