Bradfield J W
Br J Exp Pathol. 1980 Dec;61(6):617-23.
The characteristics of so-called reticuloendothelial blockade have been reinvestigated in mice using organ uptake, rather than blood clearance, as the main method of assessment. Blockade was induced by using i.v. dextran sulphate. I.v. 51Cr-labelled sheep red blood cells were used as test particles. Although clearance of colloid from the bloodstream induced prolongation of reticuloendothelial clearance of a subsequent dose of test particles, this was solely due to depression of hepatic phagocytosis and the splenic and bone-marrow clearance remained unimpaired. Because of this highly selective action of i.v. blockading colloid, and because testing via the i.v. route can only provide information about macrophages which line blood channels, the expression reticuloendothelial blockade is entirely inappropriate to describe these phenomena. Unexpectedly, the effects could be quantitated using a wide range of doses of this test particle and saturating doses were not required.
利用器官摄取而非血液清除作为主要评估方法，在小鼠身上对所谓的网状内皮系统阻滞的特征进行了重新研究。通过静脉注射硫酸葡聚糖诱导阻滞。静脉注射用51Cr标记的绵羊红细胞作为测试颗粒。尽管从血流中清除胶体导致随后剂量的测试颗粒的网状内皮系统清除时间延长，但这完全是由于肝吞噬作用受到抑制，而脾脏和骨髓的清除功能未受损害。由于静脉注射阻滞胶体具有这种高度选择性作用，并且由于通过静脉途径进行测试只能提供关于衬在血窦的巨噬细胞的信息，因此“网状内皮系统阻滞”这一表述完全不适用于描述这些现象。出乎意料的是，使用各种剂量的这种测试颗粒都可以对这些效应进行定量，并不需要饱和剂量。
