Sitarska E, Kostrzewska E, Konopka L, Sokołowska K
Acta Haematol Pol. 1979 Oct;10(4):275-81.
The purpose of this study was evaluation of the phagocytic ability of peripheral blood leucocytes and reticuloendothelial system of the lungs, liver and spleen after one infusion of plasma-substituting preparations: Fluigel and dextran 70 in volumes of 20 ml/kg of body weight. The experiments were done in rabbits. The response of the reticuloendothelial system was assessed on the basis of its ability of eliminating foreign erythrocytes labelled with 51Cr from the circulating blood and radioactivity accumulation in the liver and spleen. It was found that infusion of Fluigel and dextran produced transient changes in the function of the reticuloendothelial system with increased number of granulocytes and a fall of their radioactivity 3 and 6 hours after infusion, reduced ability of pulmonary 51Cr accumulation and increased storage in the spleen observed 24 hours after infusion.
本研究的目的是评估单次输注20ml/kg体重的血浆代用品氟凝胶（Fluigel）和右旋糖酐70后，外周血白细胞以及肺、肝和脾的网状内皮系统的吞噬能力。实验在兔身上进行。基于网状内皮系统从循环血液中清除用51Cr标记的外来红细胞的能力以及肝脏和脾脏中的放射性积累来评估其反应。结果发现，输注氟凝胶和右旋糖酐后，网状内皮系统功能出现短暂变化，输注后3小时和6小时粒细胞数量增加且放射性下降，输注后24小时观察到肺51Cr积累能力降低而脾脏中的储存增加。
