Young H L, Wheeler M H, Morse D
Br J Surg. 1981 Jan;68(1):59-90. doi: 10.1002/bjs.1800680119.
A randomized controlled trial to assess the effect of intravenous Trasylol on postoperative intraperitoneal adhesion formation has been performed in rats. Before undergoing a standard left colonic resection, animals received i.v. Trasylol 10 000 KIU. This dose was repeated 8-hourly for 3 days postoperatively. Control animals received saline placebo. The mean percentage circumference of the anastomosis covered with adhesions in the Trasylol group animals was 20.86 +/- 6.08 compared with 45.24 +/- 5.97 in the control group (P less than 0.01). Significantly more animals treated with Trasylol were completely free of adhesions than those receiving saline. Bursting pressures did not differ between the two groups. Intravenous Trasylol clearly inhibits intraperitoneal adhesion formation in this model.
已在大鼠中进行了一项随机对照试验，以评估静脉注射抑肽酶对术后腹腔粘连形成的影响。在进行标准左半结肠切除术前，动物静脉注射10000 KIU抑肽酶。术后3天，每8小时重复一次该剂量。对照动物接受生理盐水安慰剂。抑肽酶组动物吻合口被粘连覆盖的平均周长百分比为20.86±6.08，而对照组为45.24±5.97（P<0.01）。接受抑肽酶治疗的动物完全没有粘连的比例明显高于接受生理盐水的动物。两组之间的破裂压力没有差异。在该模型中，静脉注射抑肽酶明显抑制腹腔粘连的形成。
