Young H L, Wheeler M H
Eur Surg Res. 1983;15(1):18-23. doi: 10.1159/000128328.
A randomized controlled trial to assess the effect of intravenously administered Trasylol on the healing of experimental colonic anastomoses in the rabbit has been performed. Before undergoing a standard left colonic resection and anastomosis, the animals received intravenous Trasylol (80,000 KIU). Postoperatively 160,000 KIU were given in divided doses per day for 3 days. Control animals received saline placebo. The mean bursting pressure of the anastomoses in the Trasylol-treated group was 47.7 +/- 3.0 mm Hg compared with 37.5 +/- 3.3 mm Hg for the control group (p less than 0.05). The mean difference in collagen content of the anastomosis compared to the resected specimen was +1.25 +/- 0.50 micrograms/mg and -1.02 +/- 0.47 microgram/mg for Trasylol and placebo, respectively (p less than 0.005). In this model intravenous Trasylol produces a significant elevation of the bursting pressure and a significant improvement in the collagen content of the anastomosis. This may be the result of collagenase inhibition.
已进行一项随机对照试验，以评估静脉注射抑肽酶对兔实验性结肠吻合口愈合的影响。在进行标准左半结肠切除和吻合之前，动物接受静脉注射抑肽酶（80,000 KIU）。术后每天分剂量给予160,000 KIU，共3天。对照动物接受生理盐水安慰剂。抑肽酶治疗组吻合口的平均破裂压力为47.7±3.0 mmHg，而对照组为37.5±3.3 mmHg（p<0.05）。与切除标本相比，抑肽酶组和安慰剂组吻合口胶原蛋白含量的平均差异分别为+1.25±0.50微克/毫克和-1.02±0.47微克/毫克（p<0.005）。在该模型中，静脉注射抑肽酶可使吻合口的破裂压力显著升高，胶原蛋白含量显著改善。这可能是胶原酶抑制的结果。
