Nakagawa T, Otz U, de Weck A L, Schneider C H
Int Arch Allergy Appl Immunol. 1981;64(2):210-6. doi: 10.1159/000232694.
The suppressive effect of cleavable penicilloylated dextran (BPO-DEX), whose directly bound penicilloyl groups undergo hydrolytic cleavage within 3 days under physiological conditions, on murine IgE antibody formation against the benzylpenicilloyl (BPO) determinant was investigated in BALB/c and C3H mice. Intraperitoneal administration of BPO-DEX during either primary or secondary IgE responses to BPO ascaris produced a reversible suppression of BPO-specific IgE, while not affecting carrier-specific IgE antibody formation. Suppression of longer duration, at least 10 weeks, was achieved, however, by repeated administrations of BPO-DEX. BPO-DEX itself did not generate detectable BPO-specific IgE antibodies. These results suggest that BPO-DEX might be one of the promising tolerogens in the prevention of penicillin allergy.
可裂解的青霉素酰化葡聚糖（BPO-DEX）在生理条件下，其直接结合的青霉素酰基团会在3天内发生水解裂解。研究了BPO-DEX对BALB/c和C3H小鼠针对苄青霉素酰（BPO）决定簇的小鼠IgE抗体形成的抑制作用。在对BPO蛔虫的初次或二次IgE反应期间腹腔注射BPO-DEX，可对BPO特异性IgE产生可逆性抑制，而不影响载体特异性IgE抗体的形成。然而，通过重复注射BPO-DEX可实现至少10周的更长时间抑制。BPO-DEX本身不会产生可检测到的BPO特异性IgE抗体。这些结果表明，BPO-DEX可能是预防青霉素过敏的有前景的耐受原之一。
