Ginsburg D S, Floyd M, Potter E, del Greco F, Levin M L
J Lab Clin Med. 1981 Mar;97(3):418-28.
We studied the behavior of AgGG, a model of iCs, in the rat. The clearance of radiolabeled AgGG from the circulation was found to follow first-order kinetics. The t1/2 of the AgGG increased markedly with increases in dose administered, whereas the absolute rate of removal appeared to approach a maximum. The bulk of the AgGG cleared was found in the liver, and less than 1% was found in spleen, lung, or kidney. All these features are typical of the behavior of macromolecules removed from the circulation by the RES. Specific glomerular deposition was studied at various dosages by isolating glomeruli and measuring the fraction of injected aggregate that was trapped. This fraction represented less than 10% of total renal deposits. Moreover, when animals were sacrificed at an interval of 1 t1/2 after the injection of the corresponding dose, the fraction deposited in glomeruli remained constant. The significance of this finding is discussed in relation to the pathogenesis of glomerulonephritis.
我们在大鼠中研究了免疫复合物（iCs）模型AgGG的行为。发现放射性标记的AgGG从循环中的清除遵循一级动力学。AgGG的半衰期随着给药剂量的增加而显著增加，而绝对清除率似乎接近最大值。清除的大部分AgGG存在于肝脏中，在脾脏、肺或肾脏中的含量不到1%。所有这些特征都是被网状内皮系统（RES）从循环中清除的大分子的典型行为。通过分离肾小球并测量被困住的注射聚集体的比例，研究了不同剂量下的特异性肾小球沉积。该比例占肾脏总沉积物的不到10%。此外，当在注射相应剂量后间隔1个半衰期处死动物时，肾小球中沉积的比例保持不变。结合肾小球肾炎的发病机制讨论了这一发现的意义。
