Miyazaki S, Kawasaki K, Yaoita E, Yamamoto T, Kihara I
Clin Exp Immunol. 1985 Feb;59(2):293-9.
We established an experimental model of immune complex glomerulonephritis (ICGN) in rats by daily i.v. administration of 2.0 mg of bovine serum albumin (BSA) for 4 weeks (Yamamoto et al., 1978). In the present study, antigen distribution among various organs was evaluated in the whole course of the experimental rat model using the paired radiolabel technique and the direct immunofluorescent method. In the late stage of chronic serum sickness (CSS), antigen distribution to the liver decreased and that to the glomeruli increased remarkedly whereas hepatic distribution of the antigen was the highest among the organs in the early stage of CSS. BSA distribution in the glomeruli correlated positively with the distribution in blood and there was an inverse relationship between glomerular distribution of BSA and hepatic distribution throughout the course of CSS. These observations may show direct evidence that events in the liver influence the development of ICGN.
我们通过每天静脉注射2.0毫克牛血清白蛋白（BSA），持续4周，建立了大鼠免疫复合物性肾小球肾炎（ICGN）的实验模型（Yamamoto等人，1978年）。在本研究中，使用配对放射性标记技术和直接免疫荧光法，在实验大鼠模型的整个过程中评估了抗原在各个器官中的分布。在慢性血清病（CSS）的晚期，肝脏的抗原分布减少，而肾小球的抗原分布显著增加，而在CSS早期，肝脏的抗原分布在各器官中是最高的。肾小球中BSA的分布与血液中的分布呈正相关，并且在CSS的整个过程中，BSA的肾小球分布与肝脏分布呈负相关。这些观察结果可能直接证明肝脏中的事件会影响ICGN的发展。
