Oka Y, Hayashi H, Ishikawa F, Osaki H
Microbiol Immunol. 1980;24(10):925-32. doi: 10.1111/j.1348-0421.1980.tb02898.x.
In order to analyze the host-parasite interactions in experimental trichomoniasis, the growth of Trichomonas foetus in the peritoneal cavity and changes in the peritoneal exudate cells were followed in mice treated with dextran sulfate 500 (DS 500), a known macrophage-toxic agent. Light microscopic observation showed that DS 500 treatment induced degeneration of peritoneal macrophages within about 48 hr after the treatment and the damaged macrophages did not phagocytize the parasites, whereas peritoneal neutrophils and lymphocytes were not affected by the drug. In the DS 500-treated mice, growth of parasites in the peritoneal cavity was accelerated and a high susceptibility of the mice to T. foetus infection was observed. These results indicate that macrophages play the most important role among the peritoneal exudate cells in resistance to T. foetus infection, especially during the early stage of infection.
为了分析实验性毛滴虫病中的宿主-寄生虫相互作用，在用已知的巨噬细胞毒性剂硫酸葡聚糖500（DS 500）处理的小鼠中，追踪胎儿三毛滴虫在腹腔中的生长以及腹腔渗出细胞的变化。光学显微镜观察显示，DS 500处理在处理后约48小时内诱导腹腔巨噬细胞变性，受损的巨噬细胞不吞噬寄生虫，而腹腔中性粒细胞和淋巴细胞不受该药物影响。在DS 500处理的小鼠中，腹腔内寄生虫的生长加速，并且观察到小鼠对胎儿三毛滴虫感染具有高度易感性。这些结果表明，巨噬细胞在腹腔渗出细胞中对胎儿三毛滴虫感染的抵抗力中起最重要作用，尤其是在感染的早期阶段。
