来自海鞘Didemnum voeltzkowi的杀结核菌素类似物。
Tubercidin analogs from the ascidian Didemnum voeltzkowi.
作者信息
Mitchell S S, Pomerantz S C, Concepción G P, Ireland C M
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.
出版信息
J Nat Prod. 1996 Oct;59(10):1000-1. doi: 10.1021/np960457f.
PMID:8904849
Abstract
Two new 5'-deoxypyrrolo[2,3-d]pyrimidine (7-deazapurine) nucleosides, 5'-deoxytubercidin and 5'-deoxy-3-bromotubercidin, were identified from the ascidian Didemnum voeltzkowi. Two known anomers of 5'-deoxy-3-iodotubercidin were also purified from the extract. Assignments were made on the basis of 1H and 13C chemical shifts as well as HPLC-MS experiments.
摘要
从海鞘Didemnum voeltzkowi中鉴定出两种新的5'-脱氧吡咯并[2,3-d]嘧啶（7-脱氮嘌呤）核苷，即5'-脱氧杀结核菌素和5'-脱氧-3-溴杀结核菌素。还从提取物中纯化出了两种已知的5'-脱氧-3-碘杀结核菌素端基异构体。根据1H和13C化学位移以及高效液相色谱-质谱实验进行了归属。
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