DiBenedetto J, Dick J F, Albala M
Ann Clin Res. 1977 Dec;9(6):330-4.
Three patients with carcinoma of the breast, extensive metastasis, and splenomegaly are described. Radioisotope studies with 59Fe and 51Cr revealed extramedullarly hematopoiesis and hemolysis. In addition to red cell hemolysis, ineffective erythropoiesis in the marrow and extramedullary sites contributed to the persistence of the anemic syndrome. Extramedullary hematopoiesis is not an effective compensatory mechanism in some patients with anemia and carcinoma of the breast.
本文描述了三名患有乳腺癌、广泛转移和脾肿大的患者。用59Fe和51Cr进行的放射性同位素研究显示存在髓外造血和溶血。除红细胞溶血外，骨髓和髓外部位无效的红细胞生成导致了贫血综合征的持续存在。在一些患有贫血和乳腺癌的患者中，髓外造血不是一种有效的代偿机制。
