Steding G, Seidl W
Thorac Cardiovasc Surg. 1980 Dec;28(6):386-409. doi: 10.1055/s-2007-1022440.
The formation of the relief of cardiac septa occurs in connexion with the development of shape of the external cardiac wall. Changes in the form of the external cardiac wall precede changes in the internal cardiac wall. The originally straight tubular heart is angulated at typical sites during cardiac looping. At the site of angulations the primary circular cross-section is deformed to an oval and is thereby narrowed. This deformation causes a growth of the endocardial and subendocardial tissue along the long sides of the oval to form protrusions into the cardiac lumen. These protrusions represent the anlagen of the fibrous cardiac septa. The site of origin of the fibrous septa is directly dependent on the direction of primary deformation. Origin and site of the ventricular septum results from the locally different directions and patterns of growth in the right and left ventricle. The anlagen of the cardiac septa are not isolated formations, but rather represent a continuous system of protrusions. Depending on the position and form of its components, their free edges grow towards each other and fuse wherever they meet.
心脏隔膜的形成与心脏外壁形状的发育相关。心脏外壁形状的变化先于心脏内壁的变化。最初呈直管状的心脏在心脏环化过程中于典型部位形成角度。在形成角度的部位，原始的圆形横截面变形为椭圆形，从而变窄。这种变形导致心内膜和心内膜下组织沿着椭圆形的长边生长，形成向心腔内突出的结构。这些突出结构代表纤维性心脏隔膜的原基。纤维性隔膜的起源部位直接取决于原始变形的方向。室间隔的起源和位置源于左右心室局部不同的生长方向和模式。心脏隔膜的原基并非孤立的结构，而是代表一个连续的突出结构系统。根据其组成部分的位置和形态，它们的自由边缘相互生长并在相遇处融合。
