Soveri P, Fyhrquist F
Ann Clin Res. 1977 Dec;9(6):346-9.
Plasma renin activity (PRA) and angiotensin II (A II) concentrations were measured in the first and second half of the menstrual cycle for four months in 27 healthy young women, in three groups. During month II and III group I received lynestrenol 0.5 mg, group II lynestrenol 0.5 mg + ethinyl estradiol 0.05 mg and group III d-norgestrel 0.25 mg + ethinyl estradiol 0.05 mg as contraceptive treatment. In group I no changes of PRA or A II were observed. In group II and III both PRA and A II rose significantly during oral contraceptive treatment. Progestagens may offer an advantage as they do not stimulate the renin-angiotensin axis.
对27名健康年轻女性分三组进行了为期四个月的观察，测量了她们月经周期前半段和后半段的血浆肾素活性（PRA）和血管紧张素II（A II）浓度。在第二个月和第三个月期间，第一组接受0.5毫克炔诺孕酮治疗，第二组接受0.5毫克炔诺孕酮 + 0.05毫克炔雌醇治疗，第三组接受0.25毫克左炔诺孕酮 + 0.05毫克炔雌醇作为避孕治疗。第一组未观察到PRA或A II的变化。在第二组和第三组中，口服避孕药治疗期间PRA和A II均显著升高。孕激素可能具有优势，因为它们不会刺激肾素 - 血管紧张素轴。
