de Castro B, Kistenmacher T J, Marzilli L G
Agents Actions Suppl. 1981;8:435-64.
A systematic review of the molecular structures of a large number of platinum(II) complexes with purine and pyrimidine bases and their nucleosides and nucleotides is presented. From these studies it is evident that the endocyclic nitrogen donor atoms of the heterocyclic purine and pyrimidine bases are dominant metal binding sites for Pt(II). Secondary interactions involving the exocyclic functional groups of the bases and the phosphate moiety of nucleotides are also noted. For Pt(II) complexes containing two adjacent (cis) bases, it is further indicated that intracomplex and intercomplex base-base interactions are of particular importance, giving rise in some cases to discontinuous helical arrays of Pt(II) complexes. These helical arrays may provide some insights into platinized-DNA polymers. Attention is also given to polynuclear species which are models for the family of mixed-valent platinum-pyrimidine blues. Finally, an attempt is made to extend the results of small molecule studies to give insights into the general area of Pt(II)-DNA chemistry and, in particular, the mode of action of the active anti-neoplastic agent cisPt.
本文对大量含有嘌呤和嘧啶碱基及其核苷和核苷酸的铂（II）配合物的分子结构进行了系统综述。从这些研究中可以明显看出，杂环嘌呤和嘧啶碱基的内环氮供体原子是铂（II）的主要金属结合位点。还注意到涉及碱基的外环官能团和核苷酸磷酸部分的二级相互作用。对于含有两个相邻（顺式）碱基的铂（II）配合物，进一步表明配合物内和配合物间的碱基 - 碱基相互作用尤为重要，在某些情况下会产生铂（II）配合物的不连续螺旋阵列。这些螺旋阵列可能为铂化 - DNA聚合物提供一些见解。还关注了作为混合价铂 - 嘧啶蓝家族模型的多核物种。最后，尝试扩展小分子研究的结果，以深入了解铂（II） - DNA化学的一般领域，特别是活性抗肿瘤药物顺铂的作用模式。
